New cancer therapy

How do newer technologies help treat cancer more effectively and make treatment less painful? 

Cancer is a global health problem, it is responsible for 1 in 6 deaths worldwide. Treating cancer has been a highly complex process, involving treatments such as traditional therapeutic approaches like chemotherapy and radiation therapy. Scientists and oncologists are researching less painful cancer therapies through the use of both pharmacological and non-pharmacological approaches, for example targeted or immunotherapy. These newer innovations stop specific cancerous cells from growing or dividing while still maintaining healthy cells in the body. Even though this method is much safer and less physically painful with fewer side effects, better life quality and a safer approach to treat cancer, it still depends on the patient and the cancer type as well.

Other traditional treatments like chemotherapy targets rapidly dividing cells including cancer cells and even healthy cells like hair cells causing other health problems adding to it. There are additionally many side effects including nausea, hair loss or infections which usual targeted therapies don’t tend to have. Radiotherapy is also another traditional method which uses radiation to focus on a specific cancerous area of your body. This changes the DNA of the tumor causing cells to die instead of spreading. It can help shrink a tumor before surgery or kill remaining cells after surgery. Even though it can be very helpful, there are still many side effects such as fatigue or digestive issues for example. As radiation damages DNA of both healthy and cancerous cells, nearby tissues can also be affected causing pain in those areas. This shows how targeted therapy may be a less painful and more effective way of treating cancer.

Targeted therapy uses drugs to treat cancer cells. There are two types of drugs, one of them is monoclonal antibodies which are injected into the human body. It is produced in a lab and uses proteins to attach to cancer cells to help the immune system to detect cancer cells better. Small molecule drugs are swallowed and it can penetrate cell membranes to target cancer cells. Patients who use this method have cancer cell receptors that will lock and block signals that cancer needs to have for it to grow. This method leaves most healthy cells alone while effectively stopping cell division. There is less nausea, hair loss or side effects but it’s still not perfect as it can only work with matching receptors, creating limitations of this method.

Immunotherapy is another helpful treatment which uses the body’s immune system to recognise and attack cancer. This is because cancer cells ‘hide’ from immune cells while immunotherapy removes those disguised. This is because cancer cells are usually too similar to healthy cells making an immune response not strong enough to destroy cancer so immunotherapy overcomes these challenges by strengthening the immune response. There are many types of immunotherapy and they are currently being studied. An example is chimeric antigen receptor or CAR-T cell therapy, modifying T cells in the blood, which are a type of cell that helps fight infections, being able to make better target cancer cells. Tumor infiltrating lymphocytes or TILs are a special type of white blood cell which has been taken from a tumor, multiplied in a lab and later returned to destroy cancer cells more effectively. Lastly, another way of treating cancer by immunotherapy is immune checkpoint inhibitors which allow the immune system to recognise and attack cancer more effectively. This can be less painful as it mostly attacks cancer cells rather than healthy tissues as well as fewer side effects to the human body. But there are still risks including over active immune reactions leading to inflammation and how not all patients qualify for immunotherapy.

Proton beam therapy or PBT is similar to radiotherapy but uses beams of protons to destroy tumor cells rather than traditional radiation. This allows oncologists to have better targets for the size and shape of the tumor as well as sparing healthy surrounding tissues. It can treat many different parts of the body including brain tumors, lung cancer, etc. making it have a wide range of parts that PBT can treat. It disrupts the tumor’s DNA and destroys tumor cells. Streams of protons will then be focused into a thin beam while a tool called a gantry rotates around the patient to ensure that the tumor can be treated in every part. This causes the tumor's DNA to be unable to repair itself causing it to shrink. This method precisely targets the tumor with high radiation while significantly less radiation towards nearby healthy cells. Side effects decrease and the chances of a secondary cancer because of radiation exposure will be less of a risk. It is shown to be very effective for some cancers and helpful towards a less painful way of being treated.

Many cancers are caused by a tumor which is rapidly growing making a constant division of unhealthy cells. The best way to treat cancer is by using a mix of treatment methods such as immunotherapy and surgery for example. So new technologies emerge and surgery can become less painful as well as faster recovery. The method of minimally invasive surgery or MIS makes only small incisions on the skin. This creates less pain after surgery and smaller scars and cuts with only 1-2 centimeters of surgical incision compared to traditional surgeries which the wound can be as big as 20 centimeters. Laserscopic technology creates higher accuracy, reduces errors and keeps it small resulting in minimal blood loss. An example of MIS which can work on cancer patients is colon surgery which can remove a tumor from the intestines. This makes the treatment of cancer better than ever with new technologies and innovations.

Due to increased treatment precisions, patients find that new cancer technologies are less painful. Advanced treatment precisions focuses on targeting cancer cells while sparing healthy tissue, and the development of less invasive or non-invasive procedures that reduce the need for large incisions or systemic drugs. There are pain reduction benefits such as Monoclonal antibody therapies: it can greatly reduce pain because they target cancer's root cause and protect healthy cells leading to less pain for patients. Minimal or non-invasive procedures are performed by utilizing smaller incisions, sometimes robotic assistance, specialized equipment which leads to fewer complications and faster recovery times compared to traditional open surgery. Newer technologies improved pain management and experience towards patients. Overall, new technologies in cancer therapy aim to maximize treatment effectiveness while significantly improving the patient's quality of life and reducing pain. 

Researchers say that newer cancer treatments may have many advantages and benefits such as reducing pain during procedures. However, there are also ethical concerns as well as difficulties in real life situations. A major ethical issue is that these new technologies are often expensive and have a higher cost of building it making it only for higher income families or developed countries causing unfairness to lower income countries. These innovative treatments are also usually given to only younger patients or people with private insurance causing an unfairness and inequality of who gets to use these better equipment. These raises ethical questions as it causes injustice in healthcare distribution. Proton beam therapy has limited specialised centers making many patients having to travel long distances adding troubles into curing diseases. Immunotherapies and targeted therapies have complex machineries and mechanisms making treatment delays and limited amount of treatment slots. 

In conclusion, modern cancer therapy such as targeted therapy, immunotherapy and proton beam therapy as well as minimally invasive surgery reduces damage to healthy cells as well as reduced painful side effects and more effective results compared to traditional therapy methods such as chemotherapy. However, this treatment does still carry small risks and the best type of therapy depends on each individual. 

Bibliography

Targeted Therapies | Understanding Targeted Therapy for Cancer Treatment | Worldwide Cancer Research. (2025, October 28). Worldwidecancerresearch.org. https://www.worldwidecancerresearch.org/cancer-and-research-information/diagnosis-prevention-and-treatment/how-do-targeted-therapies-for-cancer-work/ 

National Cancer Institute. (2022, May 31). TargetedTherapy to Treat Cancer. National Cancer Institute; Cancer.gov. https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies 

‌American Cancer Society. (2025). What Is Immunotherapy? | Immunotherapy for Cancer. Www.cancer.org; American Cancer Society. https://www.cancer.org/cancer/managing-cancer/treatment-types/immunotherapy.html 

‌Johns Hopkins Medicine. (2025). Proton Therapy. Www.hopkinsmedicine.org. https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/proton-therapy 

Is targeted cancer therapy painful? Understanding 1st chemo treatment side effects - Liv Hospital. (2025, December 29). Liv Hospital. https://int.livhospital.com/first-chemo-targeted-therapy-pain-effects/ 

‌Kim, D. J., Wells, C., Khangura, S., Alexander, C., Mulla, D. S., Farrah, K., Paulden, D. M., Tsoi, D. B., DeJean, D. D., Duthie, D. K., & Dufour, B. G. (2017). Ethical Issues. In www.ncbi.nlm.nih.gov. Canadian Agency for Drugs and Technologies in Health. https://www.ncbi.nlm.nih.gov/books/NBK531685/